粘合连接
细胞生物学
机械转化
酪氨酸磷酸化
化学
磷酸化
阿布勒
收缩性
细胞结
生物
细胞粘附
焦点粘着
钙粘蛋白
细胞骨架
信号转导衔接蛋白
肌动蛋白细胞骨架
癌症研究
信号转导
原癌基因酪氨酸蛋白激酶Src
支架蛋白
作者
Huapeng H. Yu,Jennifer A. Zallen
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-11-27
卷期号:370 (6520)
被引量:28
标识
DOI:10.1126/science.aba5528
摘要
Epithelial structure is generated by the dynamic reorganization of cells in response to mechanical forces. Adherens junctions transmit forces between cells, but how cells sense and respond to these forces in vivo is not well understood. We identify a mechanotransduction pathway involving the Abl tyrosine kinase and Canoe/Afadin that stabilizes cell adhesion under tension at tricellular junctions in the Drosophila embryo. Canoe is recruited to tricellular junctions in response to actomyosin contractility, and this mechanosensitivity requires Abl-dependent phosphorylation of a conserved tyrosine in the Canoe actin-binding domain. Preventing Canoe tyrosine phosphorylation destabilizes tricellular adhesion, and anchoring Canoe at tricellular junctions independently of mechanical inputs aberrantly stabilizes adhesion, arresting cell rearrangement. These results identify a force-responsive mechanism that stabilizes tricellular adhesion under tension during epithelial remodeling.
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