Direct Trifluoromethoxylation of Aliphatic Compounds

During the past decade, significant advances have been achieved on the direct trifluoromethoxylation of aliphatic compounds. In this section, the direct trifluoromethoxylation of alkenes, aliphatic substrates, and even CH bonds are summarized and discussed. With comparison to the traditional nucleophile substitution pathway, the transition metal catalysts (such as Pd, Ag, and Co) have started to play vital roles in the direct trifluoromethoxylation reactions. With the incorporation of transition metals, the diversity of substrates, reaction selectivities, as well as the reaction outcomes has been dramatically improved. Future investigation of C(sp3)–OCF3 formation reactions is anticipated.