医学
胚胎移植
植入失败
子宫内膜炎
重症监护医学
子宫
胚胎质量
精子质量
模式
随机对照试验
妇科
胚胎
外科
不育
精子
卵母细胞
怀孕
男科
内科学
社会学
细胞生物学
生物
遗传学
社会科学
作者
Yiğit Çakıroğlu,Bülent Tıraş
出处
期刊:Current Opinion in Obstetrics & Gynecology
[Ovid Technologies (Wolters Kluwer)]
日期:2020-06-01
卷期号:32 (3): 198-204
被引量:22
标识
DOI:10.1097/gco.0000000000000620
摘要
Purpose of review Recurrent implantation failure (RIF) refers to the absence of implantation after repeated transfer of good embryos into a normal uterus. This review discusses the diagnostic criteria and cause of RIF. Recent findings Regardless of the advancements in IVF practice, RIF is still a challenge that has to be solved. Exact definition of RIF is lacking today. For the initial evaluation, a rigorous algorithmic evaluation should be compromised with an individualized principle. Factors that might affect the number and quality of the oocyte and sperm cells should be investigated in order to obtain a good-quality embryo. Embryo assessment should be performed under ideal laboratory circumstances. The uterine environment should be carefully evaluated and the embryo should be transferred into the uterus at the most receptive time. Some of the newly introduced diseases and empirical treatment strategies, such as chronic endometritis, vaginal microbiota, immunologic profile and immunomodulator treatments, can be discussed with the couple under the light of adequate evidence-based information. Summary New diagnostic and treatment modalities are needed to be introduced, which would be safe, efficient and efficacious after well-designed randomized controlled trials.
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