Progress in the proteomics research of cerebrospinal fluid

Cerebrospinal fluid proteomics, a branch of proteomics, is aimed to separate different types of cerebrospinal fluid proteins and identify differentially expressed protein sites through core analysis techniques. Since cerebrospinal fluid is directly connected with extracellular fluid of brain tissue, the abnormal change in the central nervous system could influence the composition of cerebrospinal fluid, such as peptides and proteins. Cerebrospinal fluid proteomics research gives insight into understanding of physiological and pathological changes of central nervous system (CNS), which is a supplement of cytological examination and biochemical test for CNS, and the technology provides a support for diagnosis and treatment of CNS diseases. Detecting cerebrospinal fluid proteomics is of great importance for the diagnosis, treatment and prognosis of CNS diseases.(Chin J Lab Med, 2017, 40: 924-927) Key words: Cerebrospinal fluid; Proteomics; Central nervous system diseases