群体感应
生物
细胞信号
生物膜
信号转导
功能(生物学)
细菌
细胞生物学
毒力
自诱导物
受体
细胞内
微生物学
基因
遗传学
作者
Yingping Xiao,Huicong Zou,Jingjing Li,Tongxing Song,Wentao Li,Wen Wang,Zhenyu Wang,Shiyu Tao
出处
期刊:Gut microbes
[Informa]
日期:2022-02-19
卷期号:14 (1)
被引量:31
标识
DOI:10.1080/19490976.2022.2039048
摘要
Quorum sensing is a molecular signaling-based communication mechanism in prokaryotes. In the basic mode, signaling molecules released by certain bacteria are sensed by intracellular receptors or membrane-bound receptors of other members in the community, leading to the collective isogenic signaling molecule synthesis and synchronized activities. This regulation is important for the symbiosis of the bacterium with the host, as well as virulence and biofilm formation. Notably, quorum sensing signaling molecules are not only able to control microbial community behavior but can likewise regulate the physiological status of host cells. Here, we provide a comprehensive review of the importance of quorum sensing signaling molecules in gram-negative bacteria in regulating host cell function and gut health, and suggest possible opportunities for application in combating human and animal diseases by blocking the pathways through which quorum sensing signaling molecules exert their functions.
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