Kabachnik‐Fields Reaction

Abstract A one‐pot synthesis of α‐amino phosphonate via the three‐component coupling of aldehyde (or ketone), an amine, and a dialkylphosphite is generally referred to as the Kabachnik–Fields reaction. It has been reported ketones undergo the coupling more readily than aldehydes, especially for aliphatic ketones that react vigorously. Besides this several other reaction conditions have been discussed to achieve the optimal yields. This reaction has been applied for the preparation of α‐amino phosphonates, which are useful for chelating agents.