Liver segmentation from computed tomography images using cascade deep learning

Liver segmentation is a fundamental step in the treatment planning and diagnosis of liver cancer. However, manual segmentation of liver is time-consuming because of the large slice quantity and subjectiveness associated with the specialist's experience, which can lead to segmentation errors. Thus, the segmentation process can be automated using computational methods for better time efficiency and accuracy. However, automatic liver segmentation is a challenging task, as the liver can vary in shape, ill-defined borders, and lesions, which affect its appearance. We aim to propose an automatic method for liver segmentation using computed tomography (CT) images.The proposed method, based on deep convolutional neural network models and image processing techniques, comprise of four main steps: (1) image preprocessing, (2) initial segmentation, (3) reconstruction, and (4) final segmentation.We evaluated the proposed method using 131 CT images from the LiTS image base. An average sensitivity of 95.45%, an average specificity of 99.86%, an average Dice coefficient of 95.64%, an average volumetric overlap error (VOE) of 8.28%, an average relative volume difference (RVD) of -0.41%, and an average Hausdorff distance (HD) of 26.60 mm were achieved.This study demonstrates that liver segmentation, even when lesions are present in CT images, can be efficiently performed using a cascade approach and including a reconstruction step based on deep convolutional neural networks.