Effects of Borneol on the Pharmacokinetics of Galic Acid in Herb of Guangzao in Rats by RP-HPLC

OBJECTIVE To observe the effect of borneol on the pharmacokinetics of galic acid in rats.METHODS The concentrations of galic acid in plasma were determined by HPLC after administrating the extraction of Guangzao or Guangzao combined with borneol in rats by ig injection.The data were processed by DAS2.0 software to calculate the pharmacokinetic parameters and then to find the differences between two groups.RESULTS Both groups received Guangzao and Guangzao combined with borneol.The pharmacokinetics model of galic acid followed the two-compartment model.After combining with borneol,the peaking time and V/F of gallic acid were decreased,meanwhile,the CL/F of galic acid were increased.CONCLUSION Borneol can accelerate the transportation and absorption of gallic acid in rats.It may imply that the borneol can increase the therapeutic efficacy of Guangzao.