Therapetic effect of gabapentin and pregabalin on post-herpetic neuralgia

To observe the efficacy of gabapentin and pregabalin in the treatment of post-herpetic neuralgia(PHN).Sixty patients suffering from PHN were randomly divide into the gabapentin group and pregabalin group.The gabapentin group were treated by gabapentin 900mg/d for oral use and the pregabalin group were treated by pregabalin 150 mg/d for oral use.The period of both the two groups were 28 days.Before and after treatment,symptoms and signs of neuropathy including pain sleeping were observed The side effects and complications were observede.The vas score of both groups in each times was lower than before treatment(P 0.05)and the sleeping time was increased(P 0.05).The vas score of pregabalin group in the T2,T3,T4,T5,T6,T7 was lower than the gabapentin group(P 0.05).There were no severe drug adverse reaction in both groups.The incidences rate of drowsiness in pregabalin group was lower than the gabapentin group(P 0.05).There was no significant other adverse reaction between the two groups.Gregabalin was much safe and effective in the treatment of PHN than gabapentin.