The Enantioselective Formal Synthesis of Rhynchophylline and Isorhynchophylline

Chemistry – An Asian JournalVolume 8, Issue 3 p. 542-545 Communication The Enantioselective Formal Synthesis of Rhynchophylline and Isorhynchophylline Hailong Zhang, Hailong Zhang Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorXiaozhou Ma, Xiaozhou Ma Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorHong Kang, Hong Kang Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorLiang Hong, Liang Hong Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorProf. Dr. Rui Wang, Corresponding Author Prof. Dr. Rui Wang wangrui@lzu.edu.cn Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567 State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon (Hong Kong)Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this author Hailong Zhang, Hailong Zhang Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorXiaozhou Ma, Xiaozhou Ma Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorHong Kang, Hong Kang Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorLiang Hong, Liang Hong Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this authorProf. Dr. Rui Wang, Corresponding Author Prof. Dr. Rui Wang wangrui@lzu.edu.cn Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567 State Key Laboratory of Chiroscience and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon (Hong Kong)Key Laboratory of Preclinical Study for New Drugs of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China), Fax: (+86) 931-891-2567Search for more papers by this author First published: 13 December 2012 https://doi.org/10.1002/asia.201201046Citations: 28Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Formal attire: An enantioselective formal total synthesis of the alkaloids isorhynchophylline and rhynchophylline is described. The key steps include an organocatalyzed asymmetric Michael addition reaction and an efficient diastereoselective intramolecular iminium ion spirocyclization/lactamization cascade sequence. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description asia_201201046_sm_miscellaneous_information.pdf1.8 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume8, Issue3March 2013Pages 542-545 RelatedInformation