Therapeutic effect of Dpp-4 inhibitor on therapy in treatment of type II diabetes

In this paper,the therapeutic effect and reliability of Dpp-4 inhibitors on therapy in the newly diagnosed T2 DM patients was investigated. 120 newly diagnosed T2 DM patients were randomized into observation group and control group. The control group was given metformin,while the observation group was given Dpp-4 inhibitors and metformin for 12 weeks. The fasting plasma glucose(FPG), two-hour postprandial plasma glucose(2h PG),hemoglobin A1c(Hb A1c),body mass index(BMI) and the incidence of hypoglycemia in both groups were observed. After 12-weeks treatment,the levels of 2h PG and Hb A1 c decreased significantly in observation group compared with the control group(P 0.05). The targeting rate of Hb A1 c in the observation group was 82% that was significantly higher than that of control group(P 0. 05). The changes in BMI and the incidence of hypoglycemia of two groups were not significantly different(P 0. 05). The combination of Dpp-4 inhibitors with metformin was more effective for the treatment of newly diagnosed T2 DM.