Related Research in Mammalian Target of Rapamycin Signaling Pathway and Autophagy

Autophagy is a very conservative catabolism process in the biological evolution,in which cells use double membrance vacuole packaging cytoplasmic contents to form autophagy,and then the autophagy fuses together w ith the lysosomes to degrade cytoplasmic contents and organs,maintaining and updating the animals' organelles. Mammalian target of rapamycin( mTOR) have tw o forms: mTORC1 and mTORC2,and mTOR can regulate cell grow th and proliferation according to the levels of nutrition,energy and grow th factor. This review summarizes the function and regulatory mechanism of mTOR,autophagy and the contact betw een mTOR and autophagy