Structure-analgesic activity relationships in a set of 2-aminobenzamide derivatives.

A set of 2-aminobenzamide derivatives designed as analgesic following the principles of correlation analysis have been prepared and tested. The analgesic effects shown by these products are similar to those of non-narcotic analgesic drugs; moreover, they do not show antipyretic effects and are inactive or very poor inhibitors of prostaglandin synthesis. Quantitative structure-activity relationships (QSAR) show that the analgesic potency (writhing test) is a function of the octanol-water partition coefficient. The predictive value of a correlation equation previously published is clearly demonstrated.