[Objective] To explore the clinical effect of hyperbaric oxygen combined malxone in treatment of acute alcoholism.[Methods]160 cases of acute alcoholism were divided into 2 groups,hyperbaric oxygen group(80 cases)and control group(80 cases),therapeutic effects were observed and compared.[Results] In the hyperbaric oxygen group,both light and heavy patients were significantly better than the control group in the restoration of consciousness and symptoms disappearing in time(P0.01).[Conclusion]The therapy of hyperbaric oxygen combined nalxone has a significant curative effect on the acute alcoholism,with security of clinical application.