Function of Transcription Factor PU.1 in Haematopoietic Differentiation

PU.1 is a member of the Ets transcription family and is predominantly expressed in haematopoietic cells such as myeloid cells and B lymphoid cells.PU.1 regulates the expression of a number of myeloid gene and the haematopoietic differentiation.The disruption of PU.1 function is involved in acute myeloid leukemia.