Objective:To explore the feasibility of the diagnosis of hypertrophic cardiomyopathy through analyzing clinical symptoms and signs,electrocardiogram and echocardiography,and to discuss the causes of misdiagnosis. Method:The clinical data of 36 cases with hypertrophic cardiomyopathy was analyzed. Result:Hypertrophic cardiomyopathy has diverse clinical manifestations and lack of specificity.So it is easy to be misdiagnosed,which requires us to make comprehensive consideration.Echocardiography examination can be used as the preferred method of clinical diagnosis and review. Conclusion:In order to reduce the rate of misdiagnosis and to early treat,we should improve the understanding of hypertrophic cardiomyopathy.