支气管肺泡灌洗
表型
免疫学
炎症
肺
微生物群
免疫系统
基础(医学)
医学
生物
TLR4型
病理
基因
内科学
生物信息学
胰岛素
生物化学
作者
Leopoldo N. Segal,José C. Clemente,J.J. Tsay,Brian C. Keller,Benjamin G. Wu,Yonghua Li,Nan Shen,Elodie Ghedin,Alison Morris,Phillip Diaz,Laurence Huang,William R. Wikoff,Carles Úbeda,Alejandro Artacho,William N. Rom,Daniel H. Sterman,Ronald G. Collman,Martin J. Blaser,Michael D. Weiden
出处
期刊:Nature microbiology
日期:2016-04-04
卷期号:1 (5)
被引量:442
标识
DOI:10.1038/nmicrobiol.2016.31
摘要
Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotypeSPT) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotypeSPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface. Enrichment of oral microbiota in the bronchoalveolar lavage of apparently healthy people is associated with a pro-inflammatory phenotype, suggesting that aspiration-derived microbiota play a role in regulating basal inflammatory status.
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