The impact of small phenolic metabolites of flavonoids (propionic acids) on the iron-catalysed Fenton reaction

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacognosis and Pharmaceutical Botany Candidate: Sára Spiller Supervisor: PharmDr. Zuzana Lomozová, Ph.D. Title of diploma thesis: The impact of small phenolic metabolites of flavonoids (propionic acids) on the iron-catalysed Fenton reaction Keywords: iron, flavonoid, Fenton reaction, antioxidant, pro-oxidant Iron is an essential element, necessary for the proper functioning of the human body. It is involved in many cellular processes where it acts as a cofactor. It is physiologically very important, especially for its ability to readily accept and deliver electrons. Its amount in the body is strictly regulated because in excess of the free metal, harmful radical reactions and the development of oxidative stress could result. Oxidative stress is responsible for many pathological processes. Flavonoids are natural polyphenolic substances that are found in many plants. Their consumption is associated with beneficial effects on human health, including antioxidant, anti-inflammatory, and cardioprotective properties. Despite their beneficial effects, they may, under certain circumstances, possess pro-oxidant effects related to their redox properties. During the metabolism of flavonoids, the gut microbiome degrades them to simple...