先天免疫系统
生物
神经元
神经科学
TRPV1型
免疫
细胞生物学
免疫系统
瞬时受体电位通道
感觉神经元
免疫学
受体
中枢神经系统
生物化学
作者
Jonathan Cohen,Tara N. Edwards,Andrew W. Liu,Toshiro Hirai,Marsha Ritter Jones,Ja-Ling Wu,Yao Li,Shiqun Zhang,Jonhan Ho,Brian M. Davis,Kathryn M. Albers,Daniel H. Kaplan
出处
期刊:Cell
[Elsevier]
日期:2019-08-01
卷期号:178 (4): 919-932.e14
被引量:208
标识
DOI:10.1016/j.cell.2019.06.022
摘要
Summary
Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered questions are whether TRPV1+ neuron activation in isolation is sufficient to initiate innate immune responses and what is the biological function for TRPV1+ neuron-initiated immune responses. We used TRPV1-Ai32 optogenetic mice and cutaneous light stimulation to activate cutaneous neurons in the absence of tissue damage or pathogen-associated products. We found that TRPV1+ neuron activation was sufficient to elicit a local type 17 immune response that augmented host defense to C. albicans and S. aureus. Moreover, local neuron activation elicited type 17 responses and augmented host defense at adjacent, unstimulated skin through a nerve reflex arc. These data show the sufficiency of TRPV1+ neuron activation for host defense and demonstrate the existence of functional anticipatory innate immunity at sites adjacent to infection that depends on antidromic neuron activation.
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