对氧磷酶
胆固醇转移蛋白
内科学
内分泌学
胆固醇
胆固醇酯
化学
结直肠癌
甾醇O-酰基转移酶
高密度脂蛋白
电源1
卵磷脂
载脂蛋白B
医学
氧化应激
脂蛋白
癌症
生物化学
基因
基因型
作者
M Mihajlović,Tamara Gojković,Sandra Vladimirov,Milica Miljković,Aleksandra Stefanović,Jelena Vekić,Aleksandra Zeljković,Bratislav Trifunović,Jelena Kotur‐Stevuljević,Vesna Spasojević‐Kalimanovska
标识
DOI:10.1016/j.clinbiochem.2018.11.010
摘要
Previous studies revealed decreased level of high-density lipoprotein cholesterol (HDLC) as important factor for development of colorectal cancer (CRC). Quantity and structure of HDL particles depend on activities of lipid transfer proteins lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP), but this topic is largely unexplored in CRC. The main objective of this study was to investigate activities of LCAT and CETP in patients with CRC. Additionally, we analyzed activity of paraoxonase-1 (PON-1), as a main carrier of HDL-antioxidant function. Ninety-nine CRC patients and 101 healthy individuals were included. LCAT and CETP activities were assessed by measuring rates of formation and transfer of cholesteryl esters. PON-1 paraoxonase and arylesterase activities were measured. Lower levels of HDL-C (p < .001) were observed in cohort of patients, alongside with decreased LCAT (p < .050) and increased CETP activity (p < .050). Both PON-1 activities were diminished in CRC (p < .050 and p < .001 respectively). Univariate logistic regression singled out HDL-C level (OR = 0.218, p < .001), CETP activity (OR = 1.010, p < .01) and mass (OR = 0.994, p < .001) as possible markers of elevated CRC risk. CETP mass maintained its predictive significance when adjusted for traditional risk factors and level of oxidative stress (OR = 0.993, p < .001; OR = 0.982, p < .050, respectively). Our results demonstrated increased CETP and decreased LCAT and PON-1 activities in CRC patients. In preliminary analysis CETP mass was identified as potential significant predictor of CRC development, suggesting that alterations in HDL-C levels, alongside with changes in HDL structure might have a role in carcinogenesis.
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