Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women

普雷沃菌属 放线菌 生物 持久性(不连续性) HPV感染 微生物群 内科学 宫颈上皮内瘤变 宫颈癌 生理学 医学 癌症 遗传学 细菌 工程类 岩土工程
作者
Ronghai Wu,Eiling Wu,Siriguleng Zheng,Jiandong Wang,Yaqin Ling,Yan Wang
出处
期刊:Cancer Prevention Research [American Association for Cancer Research]
卷期号:12 (1): 43-56 被引量:31
标识
DOI:10.1158/1940-6207.capr-18-0233
摘要

Abstract The aim of this study was to investigate the associations between cervical microbiota and different human papillomavirus (HPV) infection statuses in cytologically normal women. The cervical microbiota of HPV-positive or -negative women with a normal cytologic diagnosis was characterized and compared using 16S rDNA-based high-throughput sequencing, and the differences in cervical microbiota associated with new acquisition, persistence, and clearances of HPV genotypes were analyzed via one-year follow-up. The results showed that the cervical microbial richness of HPV-positive women was lower than for HPV-negative women, and the difference was more significant in the postmenopausal group relative to the premenopausal group. Ureaplasma parvum and related taxa were associated with baseline HPV positivity, while Brochothrix, Diplorickettsia, Ezakiella, Faecalibacterium, and Fusobacterium genera and their related taxa and Pseudomonas aeruginosa were associated with baseline HPV negativity. For HPV-positive women, the baseline abundance of Actinomyces was negatively associated with new HPV infection, Alloprevotella tannerae, Prevotella nigrescens, and Prevotella oulorum; and Dialister invisus were positively associated with new HPV-type infection within the year of follow-up. Lactobacillus delbrueckii was found to be negatively associated with persistent HPV infection and 9 taxa belonging to Prevotella, Dialister, and Lachnospiraceae were found to be positively associated with persistence, and/or negatively associated with clearance of HPV types. We also observed 10 novel taxa associated with the clearance/persistence of HPV that had not been reported elsewhere. Those taxa associated with different infection statuses of HPV could be used as a biomarker to help predict the risk of developing persistent HPV infection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
假装有昵称完成签到,获得积分10
3秒前
林英欣发布了新的文献求助50
6秒前
lp完成签到 ,获得积分10
6秒前
英勇如霜完成签到 ,获得积分10
7秒前
miracle完成签到 ,获得积分10
8秒前
gengwenjing完成签到,获得积分10
10秒前
朴实初夏完成签到 ,获得积分10
11秒前
天才小能喵完成签到 ,获得积分0
12秒前
Rain完成签到,获得积分10
15秒前
夏雨完成签到 ,获得积分10
15秒前
jiejie完成签到,获得积分10
17秒前
看不见的蛋炒饭完成签到 ,获得积分10
18秒前
望向天空的鱼完成签到 ,获得积分10
19秒前
桐桐应助武雨寒采纳,获得10
20秒前
20秒前
fatcat完成签到,获得积分10
21秒前
naughty完成签到,获得积分20
23秒前
炕上的西西弗完成签到 ,获得积分10
24秒前
butterflycat完成签到,获得积分10
24秒前
26秒前
zhang完成签到 ,获得积分10
26秒前
黄紫红完成签到 ,获得积分10
28秒前
29秒前
Maestro_S应助科研通管家采纳,获得20
29秒前
Maestro_S应助科研通管家采纳,获得20
29秒前
华仔应助科研通管家采纳,获得10
29秒前
Maestro_S应助科研通管家采纳,获得20
30秒前
Maestro_S应助科研通管家采纳,获得20
30秒前
30秒前
SciGPT应助科研通管家采纳,获得80
30秒前
晚来客应助科研通管家采纳,获得10
30秒前
ycd完成签到,获得积分10
30秒前
剑履上殿完成签到,获得积分10
33秒前
引子完成签到,获得积分10
33秒前
DONG发布了新的文献求助30
33秒前
不安愚志完成签到 ,获得积分10
35秒前
精明芷巧完成签到 ,获得积分10
36秒前
舟遥遥完成签到,获得积分10
37秒前
AFF完成签到,获得积分10
38秒前
高分求助中
(应助此贴封号)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
中国兽药产业发展报告 1000
Biodegradable Embolic Microspheres Market Insights 888
Quantum reference frames : from quantum information to spacetime 888
Pediatric Injectable Drugs 500
La RSE en pratique 400
ASHP Injectable Drug Information 2025 Edition 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4430616
求助须知:如何正确求助?哪些是违规求助? 3907525
关于积分的说明 12139063
捐赠科研通 3553542
什么是DOI,文献DOI怎么找? 1950285
邀请新用户注册赠送积分活动 990306
科研通“疑难数据库(出版商)”最低求助积分说明 886276