托法替尼
情感(语言学)
医学
激酶
功能(生物学)
巨噬细胞
免疫学
化学
细胞生物学
生物
生物化学
心理学
沟通
类风湿性关节炎
体外
作者
Leonie C.S. De Vries,José Duarte,Manon de Krijger,Olaf Welting,Patricia H. P. van Hamersveld,F W M Van Leeuwen-Hilbers,Perry D. Moerland,Aldo Jongejan,Geert D’Haens,Wouter J. de Jonge,Manon E. Wildenberg
摘要
JAK1i and tofacitinib but not JAK3i induce phenotypical and functional characteristics of anti-inflammatory macrophages, suggesting JAK1 as the main effector pathway for tofacitinib in these cells. In vivo, JAK1i and tofacitinib modestly affect acute rescue DSS-induced colitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI