化学
酰化
酰胺
可见光谱
接受者
卤化物
光化学
电子受体
氰化物
乙醚
光催化
组合化学
作者
Hong-Hao Zhang,Shouyun Yu
标识
DOI:10.1021/acs.orglett.9b01169
摘要
A visible-light-induced radical acylation of imines with α-ketoacids has been achieved, enabled by an electron-donor-acceptor (EDA) complex. This EDA complex-mediated process eradicates the use of a photocatalyst. Visible light is used as the sole promoter for this reaction, and CO2 is the only side product. Substrates with amide, cyanide, ester, ether, halides, and heterocycles were compatible. This radical acylation allows access structurally diverse α-amino ketones (32 examples) in up to 90% isolated yields.
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