微气泡
材料科学
药物输送
生物医学工程
超声波
回声
体内
超声成像
纳米技术
靶向给药
超声科
纳米医学
医学
放射科
纳米颗粒
生物技术
生物
作者
Laura Emma Andrews,Ming‐Hsien Chan,Ru‐Shi Liu
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2019-02-20
卷期号:30 (18): 182001-182001
被引量:15
标识
DOI:10.1088/1361-6528/aafeb9
摘要
Applying nanobubbles (NBs) for contrast-enhanced ultrasound imaging has received increased attention. NBs are biocompatible, multifunctional, theranostic agents. Their properties of high echogenicity and stability create an agent suitable for ultrasonography diagnosis. Their favorable properties of size, in vivo stability, and ease of modification are being exploited to implement a theranostic platform for cancer treatment. The considerable development offers the potential to overcome drug resistance and adverse side effects that are associated with traditional chemotherapy. This review outlines the principles of ultrasonography and angiogenesis. Microbubbles and micelles are also discussed to underline the superior capabilities of NBs for the application. NBs could passively accumulate to tumor tissue by enhanced permeability and retention effect. In addition, it can also achieve the active transportation by surface modification. Active targeting modalities and stimuli-responsive drug delivery modifications generate a therapeutic vehicle. The cytotoxicity of NBs formulations, multimodal imaging capability, active targeting mechanisms, and drug delivery methods are highlighted to confirm the NB as a vehicle for targeted treatment and enhanced ultrasound imaging.
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