免疫原性
病毒学
流感疫苗
CpG寡核苷酸
生物
免疫学
医学
接种疫苗
抗体
基因
遗传学
基因表达
DNA甲基化
作者
Amirul Islam Mallick,Payvand Parvizi,Leah R. Read,Éva Nagy,Shahriar Behboudi,Shayan Sharif
出处
期刊:Vaccine
[Elsevier]
日期:2011-02-01
卷期号:29 (8): 1657-1665
被引量:46
标识
DOI:10.1016/j.vaccine.2010.12.046
摘要
Influenza virosomes are virus-like particles, representing a platform for vaccine development. In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIFN-γ) or CpG-ODN in chickens. Immunization with virosomes adjuvanted with CpG-ODN elicited the highest haemagglutination inhibition antibody titres, as well as IgG and IgA serum antibody responses. Moreover, Virosomes+CpG-ODN formulation induced an antigen-specific spleen cell proliferation and IFN-γ expression. In conclusion, our results demonstrated that virus-specific antibody- and cell-mediated responses may be induced in chickens immunized with virosomes and these responses can be enhanced by incorporating CpG-ODN in the virosome vaccine formulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI