葛兰素史克-3
糖原合酶
生物
细胞生物学
GSK3B公司
磷酸化
激酶
蛋白激酶A
神经科学
作者
Richard S. Jope,Gail V.W. Johnson
标识
DOI:10.1016/j.tibs.2003.12.004
摘要
Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly large number of cellular processes and diseases. Several mechanisms play a part in controlling the actions of GSK3, including phosphorylation, protein complex formation, and subcellular distribution. These are used to control and direct the far-reaching influences of GSK3 on cellular structure, growth, motility and apoptosis. Dysregulation of GSK3 is linked to several prevalent pathological conditions, such as diabetes and/or insulin resistance, and Alzheimer's disease. Therefore, much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of GSK3 in pathological conditions.
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