美金刚
NMDA受体
莫里斯水上航行任务
敌手
药理学
心理学
神经科学
医学
内科学
受体
海马体
作者
Mohammed Filali,Robert Lalonde,Serge Rivest
标识
DOI:10.1016/j.neuropharm.2011.01.035
摘要
Glutamate neurotoxicity has been proposed to be involved in Alzheimer pathogenesis, with clinical data supporting successful treatment with the NMDA receptor antagonist memantine. In the present study, the effects of subchronic memantine administration were assessed on spatial and non-spatial learning as well as exploratory activity and nest-building in APP/PS1 mutant mice. Memantine (10 mg/kg, i.p.) was better than placebo during the reversal phase of left-right discrimination, though equivalent to saline for Morris water maze and passive avoidance learning. The drug had no effect on non-learned behaviors in elevated plus-maze exploration and nest-building. These results support a specific action of the NMDA receptor antagonist on behavioral flexibility in mutant mice with amyloid pathology.
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