医学
雌激素
尿失禁
临床试验
雌激素疗法
随机对照试验
雌激素替代疗法
数据提取
妇科
内科学
泌尿科
梅德林
政治学
法学
作者
Carmen J. Sultana,Mark D. Walters
出处
期刊:Maturitas
[Elsevier]
日期:1994-12-01
卷期号:20 (2-3): 129-138
被引量:79
标识
DOI:10.1016/0378-5122(94)90008-6
摘要
The purpose of this study was to review the efficacy of estrogen therapy for urinary incontinence by examining published trials and to review the epidemiologic and physiologic evidence for its action.Controlled and uncontrolled trials of estrogen therapy in the English literature were collected. Eight controlled and 14 uncontrolled trials were identified.Trials were selected if they were prospective. All types of estrogen treatment were included. All types of outcome measurements were included.Trials were categorized by type of estrogen used; outcome variables (subjective improvement vs objective urodynamic data); and cure/improvement rates.Published trials do not support estrogen replacement as efficacious therapy for stress urinary incontinence. It may be useful for incontinence associated with urgency and frequency. Adequately large controlled trials that evaluate estrogen replacement regimens used in the USA remain to be done.
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