A novel experimental method to evaluate motor task control in Parkinson's patients

In this paper, a novel experimental method was developed to study planar arm movement control in tremor dominant Parkinson's (PD) patients. The method utilized a ball-bearing supported fiberglass brace apparatus against gravity to maintain the upper extremity in the horizontal plane. Subjects can perform postural and movement tasks with minimum damping effects. Arm movements were recorded using the MotionMonitor II system concurrently with EMGs of multiple muscles. Testing results in normal subjects with and without the brace support showed that the inertia and damping effects were negligible for oscillatory arm movement at maximum voluntary frequency (MVF). The tremor behaviors in horizontal posture maintenance and reaching movement in three PD subjects were also obtained with this method. The average frequency of postural tremor was 4.34 ± 0.15 Hz in all arm positions tested. However, the tremor magnitudes changed significantly with posture locations. In performing reaching movements, the tremor was inhibited prior to reaching, but resumed after reaching. These results may provide interesting insights into the pathological mechanisms of Parkinsonian tremor, as well as the modular nature of neural control of movements.