倍半萜
化学
辛娜拉
糖苷
亚甲基
部分
立体化学
行动方式
植物
有机化学
生物化学
生物
作者
Hiroshi Shimoda,Kiyofumi Ninomiya,Norihisa Nishida,Tomoe Yoshino,Toshio Morikawa,Hisashi Matsuda,Masayuki Yoshikawa
标识
DOI:10.1016/s0960-894x(02)00889-2
摘要
The methanolic extract from the leaves of artichoke (Cynara scolymus L.) was found to suppress serum triglyceride elevation in olive oil-loaded mice. Through bioassay-guided separation, sesquiterpenes (cynaropicrin, aguerin B, and grosheimin) were isolated as the active components together with new sesquiterpene glycosides (cynarascolosides A, B, and C). The oxygen functional groups at the 3- and 8-positions and exo-methylene moiety in α-methylene-γ-butyrolactone ring were found to be essential for the anti-hyperlipidemic activity of guaiane-type sesquiterpene. In addition, inhibition of gastric emptying was shown to be partly involved in anti-hyperlipidemic activity.
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