医学
放射性肠炎
肠系膜淋巴结
胃肠病学
放射治疗
肠炎
空肠
回肠
盲肠
益生菌
肠内给药
内科学
粘液
病理
脾脏
肠外营养
生物
生态学
细菌
遗传学
作者
Seher Demirer,Semih Aydıntuğ,Belma Aslım,İlknur Kepenekçi,Neriman Şengül,Oya Evirgen,Devran Gerçeker,Meltem Nalça Andrieu,Cemal Ulusoy,Serçin Karahüseyinoğlu
出处
期刊:Nutrition
[Elsevier]
日期:2006-02-01
卷期号:22 (2): 179-186
被引量:62
标识
DOI:10.1016/j.nut.2005.08.003
摘要
Radiotherapy is an important aspect of multimodal cancer therapy, but radiation-induced acute intestinal injury is a common and serious problem. Disruption of morphologic mucosal integrity and normal bacterial microflora after abdominal radiation leads to malabsorption and bacterial translocation. Lactobacillus bulgaricus strain isolated from yogurt was given as a probiotic to rats subjected to radiotherapy. On postradiation day 8 rats were killed. Mesenteric lymph nodes, liver, and spleen were excised for microbiologic examinations. Segments of jejunum, ileum, and colon were evaluated for the presence of inflammation, vascularity, and mucus cells. The results of this study suggest that probiotics may have a protective effect on intestinal mucosa. Probiotics added as substrates can be given by an oral or enteral route to patients who undergo radiotherapy to prevent radiation-induced enteritis and related malnutrition.
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