促红细胞生成素肝细胞(Eph)受体
以法林
生物
细胞生物学
受体
受体蛋白酪氨酸激酶
细胞粘附
EPH受体A2
细胞迁移
受体酪氨酸激酶
细胞
斑马鱼
Notch信号通路
信号转导
遗传学
作者
Alexei Poliakov,Marisa L. Cotrina,David Wilkinson
标识
DOI:10.1016/j.devcel.2004.09.006
摘要
Abstract
Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and adhesion of cells required to form and stabilize patterns of cell organization during development. Activation of Eph receptors or ephrins can lead either to cell repulsion or to cell adhesion and invasion, and recent work has found that cells can switch between these distinct responses. This review will discuss biochemical mechanisms and developmental roles of the diverse cell responses controlled by Eph receptors and ephrins.
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