Abstract Monozygotic (MZ) twins raised in different countries and cultures are rare. This report examines behavioral and physical similarities and differences of MZ female twins from South Korea, but raised separately in the United States and France. Analyses of the twins’ intelligence, special cognitive abilities, personality traits, self-esteem, job satisfaction and health histories are considered with reference to their genetic relatedness and rearing conditions. Both striking similarities and intriguing differences were noted.