Isolation and Characterization of Ciprofloxacin-HCL Crystals

Three crystalline and one amorphous form of Ciprofloxacin-HCL were prepared and characterized by various instrumental techniques. The hygroscopicity, stability, and solubility of all the forms were also determined. Results indicated that all three crystalline and one amorphous form had distinctly different properties. Form I and II were identified as hydrates and Form III as dimethyl formamide (DMF) solvate. Stability determination of various forms under different conditions indicated that Form II was most stable against temperature and Form I against humidity. Among crystal forms, Form I was found to possess maximum aqueous solubility and was expected to exhibit maximum bioavailability.