Synthesis of Fe3O4@SiO2@PMMA Core–Shell–Shell Magnetic Microspheres for Highly Efficient Enrichment of Peptides and Proteins for MALDI‐ToF MS Analysis

Particularly enriching: Core–shell–shell Fe3O4§SiO2§PMMA composite microspheres (see picture; PMMA=poly(methyl methacrylate)) were synthesized readily by combining a sol-gel approach with a seeded aqueous-phase radical polymerization method. The microspheres were successfully applied toward the effective, rapid, and convenient enrichment of low-concentration peptides and proteins for mass spectrometric analysis.