Carcinoma of the Prostate

IN the 12 years since the topic was last reviewed in the Journal,1 prostatic cancer has become the most common newly diagnosed cancer in men. It is the cause of death in more than 28,000 men per year, accounting for 11 percent of cancer deaths, third in men after lung and colon cancer.2 Important questions remain about the cause and prevention of prostatic cancer, but new advances permit earlier diagnosis and more accurate staging. Curative therapy is possible for localized disease with much less morbidity than previously. In advanced disease, androgen-deprivation therapy remains the mainstay of treatment.Biology and . . .