生物
细胞代谢
细胞生物学
免疫系统
效应器
T细胞
细胞
调节器
细胞生长
功能(生物学)
代谢途径
细胞分化
新陈代谢
免疫学
生物化学
基因
作者
Nancie J. MacIver,Ryan D. Michalek,Jeffrey C. Rathmell
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2013-03-21
卷期号:31 (1): 259-283
被引量:1004
标识
DOI:10.1146/annurev-immunol-032712-095956
摘要
T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further, functionally distinct T cell subsets require distinct energetic and biosynthetic pathways to support their specific functional needs. Pathways that control immune cell function and metabolism are intimately linked, and changes in cell metabolism at both the cell and system levels have been shown to enhance or suppress specific T cell functions. As a result of these findings, cell metabolism is now appreciated as a key regulator of T cell function specification and fate. This review discusses the role of cellular metabolism in T cell development, activation, differentiation, and function to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.
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