Molecular Self‐Assembly of Cyclic Dipeptide Derivatives and Their Applications

Abstract Cyclic dipeptides (CDPs) are heterocyclic 2,5‐diketopiperazines with exceptional structural rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take part in intermolecular interactions. Strong intermolecular interactions driven by unique hydrogen bonding patterns render CDPs with a high propensity to undergo molecular self‐assembly. In this Review, the aim is to provide a comprehensive summary of design strategies used to engineer the molecular self‐assembly of CDPs into functional nano‐ and micro‐architectures and molecular gels with potential applications in biomedical and materials engineering fields.