血管生成拟态
血管内皮生长因子
免疫组织化学
血管内皮生长因子C
基质金属蛋白酶
医学
癌症
内科学
病理
转移
血管内皮生长因子A
胃肠病学
血管内皮生长因子受体
作者
Jingfang Lv,Baocun Sun,Hongxia Sun,Yanhui Zhang,Junying Sun,Xiulan Zhao,Qing Gu,Xueyi Dong,Na Che
出处
期刊:Oncology Research and Treatment
[S. Karger AG]
日期:2017-01-01
卷期号:40 (1-2): 35-41
被引量:17
摘要
The purpose of this study was to evaluate the clinical significance and prognostic roles of vasculogenic mimicry (VM) and elucidate their intrinsic association with molecular markers.89 human gastric cancer cases with detailed follow-up and clinicopathologic data were collected. CD34/periodic acid-Schiff double staining was performed to validate the existence of VM. Immunohistochemistry was performed to explore the expression of different molecular factors.VM was observed in 24 gastric cancer patients. They were prone to higher histological grade, hematogenous metastasis, distant recurrence, and chance of progression to stage III or IV (p < 0.05). The VM group had shorter overall and disease-free survival (p < 0.05). VM negativity was independently prognostic for prolonged overall or disease-free survival (p < 0.05). VM was positively associated with levels of matrix metalloproteinase-2, matrix metalloproteinase-9, vascular endothelial growth factor, and vascular endothelial growth factor receptor-1 (p < 0.05), but not with vascular endothelial growth factor receptor-2 (p > 0.05).VM should be regarded as a good marker to indicate pathobiological behaviors of gastric cancer. Using antibodies against matrix metalloproteinases, vascular endothelial growth factor, or vascular endothelial growth factor receptors could be strategies to counteract VM formation.
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