Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration

软骨 自愈水凝胶 再生(生物学) 丝素 软骨发生 细胞外基质 材料科学 粘附 硫酸软骨素 伤口愈合 生物医学工程 细胞生物学 胶粘剂 解剖 糖胺聚糖 纳米技术 复合材料 丝绸 生物 医学 免疫学 高分子化学 图层(电子)
作者
Fangxue Zhang,Peng Liu,Wang Ding,Qingbing Meng,Dihan Su,Qichen Zhang,Ruixian Lian,Baoqing Yu,Ming-Dong Zhao,Jian Dong,Yulin Li,Libo Jiang
出处
期刊:Biomaterials [Elsevier BV]
卷期号:278: 121169-121169 被引量:238
标识
DOI:10.1016/j.biomaterials.2021.121169
摘要

In the early stage of osteoarthritis (OA), cartilage degradation in the surface region leads to superficial cartilage defect. However, enhancing the regeneration of cartilage defect remains a great challenge for existing hydrogel technology because of the weak adhesion to wet tissue. In the present study, an injectable mussel-inspired highly adhesive hydrogel with exosomes was investigated for endogenous cell recruitment and cartilage defect regeneration. The hydrogel with high bonding strength to the wet surface was prepared using a crosslinked network of alginate-dopamine, chondroitin sulfate, and regenerated silk fibroin (AD/CS/RSF). Compared with commercial enbucrilate tissue adhesive, the AD/CS/RSF hydrogel provided a comparative lap shear strength of 120 kPa, with a similar gelation time and a higher capacity for maintaining adhesive strength. The AD/CS/RSF/EXO hydrogel with encapsulated exosomes recruited BMSCs migration and inflation, promoted BMSCs proliferation and differentiation. Most importantly, the AD/CS/RSF/EXO hydrogel accelerated cartilage defect regeneration in situ, and extracellular matrix remodeling after injection in rat patellar grooves. The exosomes released by the hydrogels could recruit BMSCs into the hydrogel and neo-cartilage via the chemokine signaling pathway. Our findings reveal an injectable and adhesive hydrogel for superficial cartilage regeneration, which is a promising approach for minimally treating cartilage defect with arthroscopic assistance.
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