阿尔法(金融)
化学
螯合作用
医学
临床心理学
结构效度
心理测量学
有机化学
作者
Soghra Farzipour,Zahra Shaghaghi,Sahar Abbasi,Hajar Albooyeh,Maryam Alvandi
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2022-05-01
卷期号:22 (8): 1496-1510
被引量:1
标识
DOI:10.2174/1871520621666210727120308
摘要
One of the most rapidly growing options in the management of cancer therapy is Targeted Alpha Therapy (TAT) through which lethal α-emitting radionuclides conjugated to tumor-targeting vectors selectively deliver high amount of radiation to cancer cells.225Ac, 212Bi, 211At, 213Bi, and 223Ra have been investigated by plenty of clinical trials and preclinical researches for the treatment of smaller tumor burdens, micro-metastatic disease, and post-surgery residual disease. In order to send maximum radiation to tumor cells while minimizing toxicity in normal cells, a high affinity of targeting vectors to cancer tissue is essential. Besides that, the stable and specific complex between chelating agent and α-emitters was found as a crucial parameter. The present review was planned to highlight recent achievements about TAT-based targeting vectors and chelating agents and provide further insight for future researches.
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