磺酰
三氟甲基
化学
氧化剂
试剂
叔醇
电化学
烯烃
组合化学
三氟甲基化
有机化学
催化作用
烷基
电极
物理化学
作者
Zhipeng Ye,Jie Gao,Xinyu Duan,Jianping Guan,Fang Liu,Kai Chen,Jun‐An Xiao,Hao-Yue Xiang,Hua Ye
摘要
An unprecedented electrochemical heterodifunctionalization of α-CF3 alkenes with benzenesulfonyl hydrazides was accomplished in this work, wherein a β-sulfonyl and a α-hydroxyl group were simultaneously incorporated across the olefinic double bond in a single operation. Consequently, a series of potentially medicinally valuable and densely functionalized α-trifluoromethyl-β-sulfonyl tertiary alcohols were assembled under mild conditions. Electrochemically-driven oxidative 1,2-difunctionlization of electron-deficient alkenes well obviates the need for oxidizing reagents, thus rendering this protocol more eco-friendly.
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