一氧化氮
化学
鸟苷酸环化酶
一氧化氮合酶
小分子
血管生成
药理学
生物化学
纳米技术
生物物理学
生物
材料科学
癌症研究
有机化学
作者
Chul Ju Yang,Seung‐Woo Jeong,Seul Kathy Ku,Kangwon Lee,Min Hee Park
标识
DOI:10.1016/j.jconrel.2018.04.025
摘要
Nitric Oxide (NO) is a small molecule gasotransmitter synthesized by nitric oxide synthase in almost all types of mammalian cells. NO is synthesized by NO synthase by conversion of l-arginine to l-citrulline in the human body. NO then stimulates soluble guanylate cyclase, from which various physiological functions are mediated in a concentration-dependent manner. High concentrations of NO induce apoptosis or antibacterial responses whereas low NO circulation leads to angiogenesis. The bidirectional effect of NO has attracted considerable attention, and efforts to deliver NO in a controlled manner, especially through polymeric carriers, has been the topic of much research. This naturally produced signaling molecule has stood out as a potentially more potent therapeutic agent compared to exogenously synthesized drugs. In this review, we will focus on past efforts of using the controlled release of NO via polymer-based materials to derive specific therapeutic results. We have also added studies and our future suggestions on co-delivery methods with other gasotransmitters as a step towards developing multifunctional carriers.
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