医学
内科学
预防性头颅照射
肺癌
阶段(地层学)
多元分析
回顾性队列研究
疾病
肿瘤科
传统PCI
生物
古生物学
心肌梗塞
作者
Xiaozhen Liu,Tao Jiang,Wei Li,Xuefei Li,Chao Zhao,Jinpeng Shi,Sha Zhao,Yuxiang Jia,Meng Qiao,Limin Zhang,Jiawei Luo,Guanghui Gao,Fei Zhou,Fengying Wu,Xiaoxia Chen,Yayi He,Shengxiang Ren,Chunxia Su
出处
期刊:Lung Cancer
[Elsevier]
日期:2018-01-01
卷期号:115: 109-115
被引量:25
标识
DOI:10.1016/j.lungcan.2017.11.022
摘要
Objectives Small-cell lung cancer (SCLC) has been viewed as a smoking-related disease, with only 2% to 5% patients being never-smokers. This study aimed to investigate the clinical characteristics of never-smoking and its association with treatment outcomes in Chinese SCLC patients in real world. Methods We performed a retrospective study of 303 patients with SCLC and grouped into smokers and never-smokers. The clinical characteristics and treatment outcomes of two groups were collected and compared. Results In total, 113 patients with limited-stage (LS) SCLC and 190 patients with extensive-stage (ES) SCLC were enrolled. Sixty-nine (22.8%) patients were never-smokers. Both the median progression-free survival (PFS) and overall survival (OS) were significantly longer in never-smokers than in smokers (PFS, 8.37 vs. 7.10 months, P = 0.036; OS, 19.73 vs. 14.40 months, P = 0.044) in all populations. Multivariate analysis suggested that never-smoking was a significant favorable prognostic factor for PFS (HR = 0.753; P = 0.047) instead of OS (HR = 0.780; P = 0.236) in patients with SCLC. The objective response rate (ORR) to first-line therapy were similar between two group (52.6% vs. 59.4%, P = 0.315). Moreover, prophylactic cranial irradiation (PCI) resulted in marginally significantly longer PFS than observation in patients with ES-SCLC who obtained objective response after first-line therapy (10.57 vs. 7.73 months, P = 0.075). Conclusion The current study indicated that never-smokers are increasingly prevalent in Chinese patients with SCLC. Never-smokers with SCLC had significantly longer PFS and OS compared with smokers, and smoking was an independent poor prognostic factor for PFS in patients with SCLC.
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