Sixty-one Sudanese patients with the nephrotic syndrome were studied. The relevant clinical and biochemical features are presented and discussed. Renal biopsy examinations showed that 12 patients (19·7%) suffered some systemic disease which was causing the nephrotic syndrome, while 49 (80·3%) had primary renal disease. Of the latter, 21 patients (34·4%) had proliferative glomerulonephritis, 13 (21·3%) had membranous glomerulonephritis, ten (16·4%) had minimal change and five (8·2%) had focal sclerosing glomerulonephritis. Amyloidosis was encountered in four patients, three of whom also had hepatosplenic schistosomiasis.