The role of Cyr61 in tumors and its clinical application

Cyr61/CCN1 is a secreted extracellular matrix (ECM) protein, which has been shown to regulate a multitude of cellular responses. Many researches indicate that Cyr61 plays important roles in oncogenesis and development of tumor and is considered to be a novel potential oncogene. This review would provide a comprehensive summary about the roles of Cyr61 in the diagnosis and treatment of tumor.(Chin J Lab Med, 2016, 39: 571-574) Key words: Neoplasms; CCN intercellular signaling proteins; Cysteine-rich protein 61; Integrins