Апоптоз: морфологические особенности и молекулярные механизмы

As provided by the paper, biological function of apop-tosis is to attain equilibrium between cell proliferation and death. The main manifestations of apoptosis occur in cell nucleus and start with DNA fragmentation. The author describes and studies a great number of endogenous mediators of apoptosis. They are: calcium, caspases, cytochrome C, family of proteins Bcl-2, Bax, TNF, p53 and growth factors. Nevertheless, in author's opinion, the major participants of apoptosis are mitochondria. The following conclusion is drawn: although over the last years, the science has advanced a lot in researching into the apoptosis, the cell death problem still remains open, and actual data are abundant and belong under category of pilot researches.