Hypoxanthine is involved in promoting the activation of mouse primordial follicles

Abstract In each wave, only a small portion of primordial follicles are selectively activated into the growing follicular pool, and the majority of primordial follicles remain in a relatively quiescent state. Hypoxanthine is present in the follicular fluid with high concentrations and inhibits phosphodiesterase (PDE) activity. $$ contribute to the promotion of the cyclic activation of primordial follicles.