生物
基因
水平基因转移
抗生素耐药性
DNA
细菌
微生物学
遗传学
微生物遗传学
抗生素
噬菌体
基因组
大肠杆菌
作者
Elisabet Marti,Eleni Variatza,José Luís Balcázar
标识
DOI:10.1111/1469-0691.12446
摘要
Six antibiotic resistance genes (blaCTX-M , blaSHV , blaTEM , qnrA, qnrB and qnrS) were quantified by qPCR in both phage and bacterial DNA fractions of environmental water samples in order to determine the contribution of phages to the dissemination of antibiotic resistance genes (ARGs) in the environment. Although the highest copy numbers (p <0.05) of ARGs were detected in the bacterial DNA fraction, qnrS and blaSHV genes were found in the phage DNA from all samples analysed, reaching up to 4 log10 copy numbers/mL in hospital samples. These results indicate that bacteriophages are a potential reservoir of resistance genes and may act as efficient vehicles for horizontal gene transfer.
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