Meta-analysis of difference in incidence of sexual dysfunction induced by mirtazapine and venlafaxine in treating patients with depression

Objective To compare the difference in incidence of sexual dysfunction induced by mirtazapine and venlafaxine in treating patients with depression.Methods A total of 12 published clinical control trials on depression treated by mirtazapine and venlafaxine were analyzed by applying fixed effects model(FEM) of evidence-based medicine(EBM).Results A total of 313 cases in 5 studies were included,and the rates of sexual dysfunction induced by mirtazapine,and venlafaxine were 0.63% and 9.74%(Z=2.96,P0.01),comprehensive OR was 0.10,and 95% CI was from 0.06 to 0.56.Conclusion Compared with mirtazapine,more attention should be paid to venlafaxine for inducing sexual dysfunction when treating depression.